Infertility

He said, "My Lord, how will I have a boy when I have reached old age and my wife is barren?" He [the angel] said, "Such is Allāh; He does what He wills."

And indeed, I fear the successors¹ after me, and my wife has been barren, so give me from Yourself an heir

He said, "My Lord, how will I have a boy when my wife has been barren and I have reached extreme old age?"

Or He makes them [both] males and females, and He renders whom He wills barren. Indeed, He is Knowing and Competent.

And his wife approached with a cry [of alarm] and struck her face and said, "[I am] a barren old woman!"